Seeing the Unseen

Publications

21. Water structure and electric fields at the interface of oil droplets

L. Shi+,*, R. A. LaCour+, N. Qian, J. P. Heindel, X. Lang, R. Zhao, T. Head-Gordon*, W. Min*, Nature, 2025, 640, 87-93

* co-corresponding author

Media reports: Nature Research Briefing, Phys.org, Bioengineer.org

Chinese Media reports: X-MOL, BioArt, 小柯化学， 科学网， 生物世界，MIT科技评论

20. Bond-Selective Imaging at the Frontier of Biomedicine

T. Wang, L. Shi*, Chem. Biomed. Imaging, 2025

19. Multi-Modal Spatial Metabolomics with Mid-Infrared Microscope Guided Mass Spectrometry Imaging

M. Wei*+, H Wang+, Y Zeng+, D. Ye, G. Wang*, L. Shi*, Journal of Visualized Experiments (JoVE), e68709

* co-corresponding authors, + co-first authors

18. Merging vibrational spectroscopy with fluorescence microscopy: combining the best of two worlds

N. Qian*, H. Xiong*, L. Wei*, L. Shi*, W. Min*, Annu. Rev. Phys. Chem., 2025, 76

* co-corresponding author

17. Illuminating life processes by vibrational probes

N. Qian , Z. Zhao , E. E. Khoury , X. Gao , C. Canela , Y. Shen , L. Shi , L. Shi, F. Hu, L. Wei, W. Min*, Nat. Methods, 2025, 22, 928–944, invited review

15. Probing the structure of water in individual living cells

X. Lang, L. Shi, Z. Zhao, W. Min*, Nat. Commun., 2024, 15, 5271-5282

14. VIBRANT: spectral profiling for single-cell drug responses

X. Liu, L. Shi, Z. Zhao, W. Min*, Nat. Methods, 2024, 21, 501-511

13. Vibrational solvatochromism study of the C-H…O improper hydrogen bond

L. Shi*, W. Min*, J. Phys. Chem. B, 2023, 127, 17, 3798-3805

* co-corresponding author

Prior to Fudan:

12. Highly-multiplexed volumetric mapping with Raman dye imaging and tissue clearing

L. Shi+, M. Wei+, Y. Miao, N. Qian, L. Shi, R. Singer, R. Benninger, W. Min*, Nat. Biotechnol., 2022, 40, 264-373

11. Super-resolution vibrational imaging using expansion stimulated Raman scattering microscopy

L. Shi, A. Klimas, B. Gallagher, Z. Cheng, F. Fu, P. Wijesekara, Y. Miao, X. Ren, Y. Zhao*, W. Min*, Adv. Sci., 2022, 2200315

10. Towards mapping mouse metabolic tissue atlas by mid-infrared imaging with heavy water labeling

X. Liu, L. Shi, L. Shi, M. Wei, Z. Zhao, W. Min*, Adv. Sci., 2022, 2105437

9. Highly-multiplexed tissue imaging with Raman dyes

L. Shi, M. Wei, W. Min*, J. Vis. Exp. 2022, (182), e63547, doi:10.3791/63547

8. 9-Cyanopyronin probe palette for super-multiplexed vibrational imaging

Y. Miao, N. Qian, L. Shi, F. Hu, W. Min*, Nat. Commun., 2021, 12, 4518

7. Mid-infrared metabolic imaging with vibrational probes

L. Shi, X. Liu, L. Shi, H. T. Stinson, J. Rowlette, L. J. Kahl, C. R. Evans, C. Zheng, L. E. P. Dietrich, W. Min*, Nat. Methods, 2020, 17, 844-851

5. Biological imaging of chemical bonds by stimulated Raman scattering microscopy

F. Hu+, L. Shi+, W. Min*, Nat. Methods, 2019, 16, 830-842.  Invited perspective

4. Stimulated Raman excited fluorescence spectroscopy and imaging

H. Xiong+, L. Shi+, L. Wei, Y. Shen, R. Long, Z. Zhao, W. Min*, Nat. Photonics., 2019, 13, 412-417

“Spectroscopy method combines the best of Raman and fluorescence” featured by Chem&Engn News.

3. Probe design for super-multiplexed vibrational imaging

Y. Miao, L. Shi, F. Hu, W. Min*, Phys. Biol. 2019, 16 (4), 041003

2. Electronic resonant stimulated Raman scattering micro-spectroscopy

L. Shi, H. Xiong, Y. Shen, R. Long, L. Wei, W. Min*, J. Phys. Chem. B, 2018, 122 (39), 9218-9224

1. Super-multiplex vibrational imaging

L. Wei, Z. Chen, L. Shi, R. Long, A. V. Anzalone, L. Zhang, F. Hu, R. Yuste, V. W. Cornish and W. Min*, Nature, 2017, 544, 465-470